O-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma
نویسندگان
چکیده
Abbreviations: AG, anaplastic glioma; BCNU, 1,3-bis( CCNU, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea; G ratio; O-meG, O-methylguanine; MGMT, O-methylgu MSP,methylation-specific PCR; PFS, progression-free surv temozolomide ⁎ Corresponding author at: Department of Neurol Washington, Box 356470, 1959 NE Pacific Street, Se Fax: +1 206 543 8315. E-mail address: [email protected] (J.R. Silber)
منابع مشابه
O6-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma
BACKGROUND CpG methylation in the O6-methylguanine-DNA methyltransferase (MGMT) promoter is associated with better outcome following alkylating agent chemotherapy in glioblastoma (GBM) and anaplastic glioma (AG). To what extent improved response reflects low or absent MGMT activity in glioma tissue has not been unequivocally assessed. This information is central to developing anti-resistance th...
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